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The Apex Predator's Reward: A Neurobiological and Physiological Analysis of Peak Performance States in Endurance Exercise

Section 1: Introduction: Deciphering the Peak Exercise Experience

1.1. Contextualizing the Phenomenon

The experience of suddenly feeling a surge of immense power during intense exercise, allowing for a sustained, high-intensity sprint for an extended period without any sensation of fatigue, is a genuine and profound state of peak human performance. While uncommon, this is not an anomaly but rather a powerful synergy of physiological adaptation, neurochemical reward, and psychological immersion. The feeling of being "unstoppable" is the subjective manifestation of a cascade of events where the body's metabolic engine, the brain's reward circuitry, and the mind's focus align perfectly. This report will deconstruct this experience, providing a scientifically grounded explanation for how the body can transcend its typical limits of fatigue and perceived effort.

1.2. The Tripartite Model

To fully comprehend this peak state, it is essential to analyze it through a tripartite model, recognizing that it is the convergence of three distinct yet interconnected phenomena: The "Second Wind": A physiological breakthrough in metabolic efficiency, where the body adapts to the stress of intense exercise by optimizing its energy production pathways. This represents the physical foundation of the experience. The "Runner's High": A neurochemical state characterized by analgesia (pain relief), anxiolysis (anxiety reduction), and euphoria. This is the brain's reward for the intense physical effort. The "Flow State": A psychological state of complete absorption in an activity, characterized by effortless performance and a loss of self-consciousness. This is the mental framework that allows the physical and neurochemical states to flourish.

1.3. Report Objective and Structure

The objective of this report is to provide a comprehensive, evidence-based analysis of the peak exercise experience by dissecting each component of the tripartite model. It will explore the underlying physiological mechanisms, the specific neurochemical pathways, and the neural correlates of the psychological state involved. Subsequently, the report will demonstrate how these three elements converge to create a synergistic, self-reinforcing loop of high performance. Finally, it will examine the factors contributing to individual variability in experiencing this state and offer evidence-based strategies for increasing its likelihood.

Section 2: The Physiological Surge: Understanding the "Second Wind"

The feeling of renewed and seemingly limitless energy is rooted in a tangible physiological event known as the "second wind." This is not merely a psychological boost but a quantifiable shift in the body's metabolic strategy in response to intense physical demand.

2.1. The Initial Strain: Oxygen Deficit and Anaerobic Metabolism

At the onset of high-intensity exercise, such as a sprint, the body's demand for adenosine triphosphate (ATP), the cellular energy currency, immediately outstrips the rate at which the cardiorespiratory system can supply oxygen to the working muscles. This creates an "oxygen deficit," forcing the muscles to rely heavily on the anaerobic energy system.1 In this state, glucose is broken down through glycolysis into pyruvate much faster than the mitochondria can process it aerobically. This excess pyruvate is rapidly converted into lactate and hydrogen ions ( H+).2 The accumulation of these hydrogen ions is what causes the familiar muscular "burning" sensation and contributes to the initial feelings of fatigue and high perceived exertion.1 This initial phase of metabolic strain is the physiological barrier that must be overcome to achieve a state of sustained performance.

2.2. The Metabolic Shift: Lactate Threshold and Enhanced Oxidative Metabolism

The lactate threshold (LT) is defined as the exercise intensity at which lactate begins to accumulate in the bloodstream faster than it can be cleared.2 For many, exceeding this threshold leads to rapid fatigue. The "second wind," however, represents a remarkable metabolic adaptation where the body successfully transitions to a state of enhanced oxidative metabolism, even while operating at a high intensity. This transition involves several key adjustments. The initial stress of the exercise bout acts as a "warm-up," inducing vasodilation and increasing blood flow to the muscles. This improves the delivery of oxygen and extramuscular fuel sources, such as blood glucose and free fatty acids.3 Critically, the body becomes more efficient at utilizing lactate itself. Rather than being a mere waste product, lactate is shuttled from the muscle fibers producing it to other fibers (particularly slow-twitch fibers) and organs like the heart and liver, where it is converted back to pyruvate and used as a high-octane fuel for aerobic energy production.1 This metabolic shift away from glycolysis and toward oxidation is a cornerstone of the second wind, allowing for a more sustainable and powerful energy output.3 A key indicator of this enhanced efficiency is observed in the body's oxygen uptake kinetics. During high-intensity exercise, a "slow component" of oxygen uptake (VO2​) typically emerges, reflecting a progressive loss of muscular efficiency. However, during a second wind, this slow component often disappears, signifying a stabilization of VO2​ and a marked improvement in skeletal muscle oxidative metabolism.3

2.3. Measurable Markers of the Second Wind

The subjective feeling of effortlessness is accompanied by objective physiological changes that mark the onset of the second wind. These markers provide clear evidence of the body's shift into a more efficient operational state. Heart Rate (HR): One of the most distinct signs of a second wind is a sudden decrease or stabilization of heart rate, even as the high-intensity exercise continues. This indicates that the cardiovascular system is no longer straining to meet the body's metabolic demands and has achieved a more efficient state of oxygen delivery.3 Oxygen Uptake (VO2​): As mentioned, the stabilization of VO2​ kinetics and the disappearance of the slow component demonstrate that the body is utilizing oxygen more efficiently to generate ATP.2 Rate of Perceived Exertion (RPE): The most profound subjective marker is a significant drop in RPE. An activity that felt strenuous and challenging moments before suddenly feels manageable or even easy. This directly corresponds to the reported experience of sprinting for 20 minutes while feeling "not tired at all".3

Section 3: The Neurochemical Cascade: The Science of the "Runner's High"

Concurrent with the physiological shift of the second wind, a powerful cascade of neurochemicals is released in the brain. This cascade is responsible for the profound psychological effects of the experience, including euphoria, painlessness, and a calm focus, collectively known as the "runner's high."

3.1. The Endorphin Hypothesis: An Incomplete Picture

For decades, the runner's high was popularly attributed to endorphins, the body's endogenous opioids.11 While it is true that intense exercise leads to a spike in circulating β-endorphin levels, and these molecules do have potent analgesic (pain-relieving) properties, this theory has a critical flaw.14 β-endorphin molecules are large peptides that cannot effectively cross the blood-brain barrier, the protective membrane that separates the bloodstream from the brain's fluid environment.11 Consequently, while peripheral endorphins can help numb muscle pain, they are unlikely to be responsible for the central psychoactive effects, such as euphoria and anxiety reduction, that define the runner's high.

3.2. The Endocannabinoid System (ECS): The True Driver of the High

Modern neuroscience has identified the endocannabinoid system (ECS) as the primary driver of the runner's high.18 The ECS is a widespread neuromodulatory system involved in regulating mood, pain, memory, and appetite. During prolonged, moderate-to-high intensity aerobic exercise—typically 30-45 minutes at 70-80% of maximum heart rate—the body significantly increases its production of endocannabinoids, particularly anandamide (AEA), often called the "bliss molecule," and 2-arachidonoylglycerol (2-AG).18 Unlike endorphins, endocannabinoids are small, lipid-based (lipophilic) molecules. This property allows them to readily pass through the blood-brain barrier and bind to cannabinoid receptors (primarily CB1 receptors) located throughout the brain.11 This binding action produces the hallmark effects of the runner's high: Analgesia: A reduction in pain perception. Anxiolysis: A significant decrease in anxiety. Euphoria: A feeling of well-being and bliss. The definitive role of the ECS has been demonstrated in studies where participants are given a drug that blocks cannabinoid receptors. In these experiments, the pain-relieving and anxiety-reducing effects of running are eliminated, providing conclusive evidence that the ECS is the crucial mediator of this state.22

3.3. The Supporting Cast: Dopamine and Norepinephrine

The ECS does not act in isolation. It interacts with other key neurotransmitter systems to orchestrate the full peak performance experience. Dopamine: The ECS directly modulates the mesolimbic dopamine pathway, a critical component of the brain's reward system. Activation of CB1 receptors enhances the release of dopamine in regions like the nucleus accumbens.23 This action does more than just create a feeling of pleasure; it powerfully reinforces the behavior of running, creating a strong motivational drive to continue the activity.30 This dopamine surge contributes to the feeling of accomplishment and the intrinsic desire to keep pushing forward. Norepinephrine: As a part of the body's stress response, norepinephrine is also released during intense exercise. It increases heart rate, mobilizes energy, and sharpens focus and alertness.31 This contributes directly to the sensation of immense power and heightened awareness reported during the peak experience.

3.4. The "Wired to Run" Hypothesis: An Evolutionary Perspective

The existence of such a potent neurochemical reward system for strenuous exercise begs an evolutionary question: why did it develop? The "Wired to Run" hypothesis, proposed by researchers like David Raichlen, offers a compelling explanation.32 It posits that early humans evolved as exceptional endurance runners to engage in "persistence hunting"—chasing prey over long distances in the heat of the day until the animal collapsed from exhaustion.32 This type of hunting is metabolically expensive and physically punishing. A neurobiological mechanism that could override signals of pain and fatigue while providing a sense of pleasure and motivation would have conferred a significant survival advantage.23 The runner's high, driven by the ECS, is theorized to be this very mechanism. It is an evolutionarily conserved reward system designed to encourage a behavior critical for our ancestors' survival. This hypothesis is supported by comparative studies showing that other cursorial (running) mammals, like dogs, also exhibit a post-exercise surge in endocannabinoids, whereas non-cursorial mammals, like ferrets, do not.23 The feeling of being "unstoppable" is, therefore, a modern echo of an ancient adaptation that enabled our ancestors to become apex predators.

Neurochemical Primary Function During Exercise Subjective Contribution to Peak Experience Anandamide (AEA) Crosses blood-brain barrier; binds to CB1 receptors; primary driver of analgesia, anxiolysis, and euphoria.18 Feelings of calm, bliss, and profound painlessness. β-Endorphin Binds to opioid receptors; primarily peripheral analgesic effects; does not effectively cross the blood-brain barrier.11 Reduction of muscle pain, but not the central feeling of euphoria. Dopamine Released in reward pathways (e.g., nucleus accumbens), modulated by the ECS.23 Drives motivation, reinforcement, and feelings of pleasure and accomplishment. Norepinephrine Increases heart rate, alertness, and focus; mobilizes energy stores.31 Sensation of power, heightened energy, and sharp awareness. Serotonin Complex role; contributes to post-exercise mood stabilization but can also be implicated in central fatigue at very high levels.19 Contributes to the lasting sense of well-being after the run is complete.

Section 4: The Psychological Immersion: Achieving a "Flow State" in Motion

The physiological capacity and neurochemical reward create the perfect conditions for a profound psychological state of immersion known as "flow." This state explains the subjective experience of the activity becoming automatic, effortless, and all-consuming.

4.1. Defining "Flow": The Psychology of Optimal Experience

Pioneered by psychologist Mihaly Csikszentmihalyi, "flow" is a state of optimal experience where a person is so involved in an activity that nothing else seems to matter.38 It is characterized by a set of distinct components, many of which align perfectly with the reported running experience: Merging of Action and Awareness: The distinction between self and the activity dissolves. One is no longer "a person running" but simply "running." Intense Concentration on the Present Moment: All focus is directed to the here and now, with past and future concerns fading away. Loss of Self-Consciousness: Worry about performance, appearance, or judgment from others disappears. A Sense of Personal Control: A feeling of confidence and mastery over the situation. Distortion of Time: Hours can feel like minutes. Autotelic Experience: The activity becomes intrinsically rewarding; it is done for its own sake. The feeling of the run becoming "effortless" is a hallmark of this deep absorption.39

4.2. The Conditions for Flow

Flow does not occur randomly. Specific conditions must be met, and the running scenario described likely fulfilled them perfectly 39: Challenge-Skills Balance: The task of sprinting is highly challenging. However, once the "second wind" was achieved and the "runner's high" began, the perceived skill level rose to meet this challenge, creating the optimal balance between boredom (too easy) and anxiety (too hard).40 Clear Goals and Immediate Feedback: The goal was unambiguous: maintain the sprint. The feedback was intrinsic and instantaneous: the rhythm of breathing, the cadence of footfalls, the feeling of movement. This constant stream of feedback allows for continuous, subconscious adjustments to maintain the state.39

4.3. The Neuroscience of Flow: Transient Hypofrontality

The neural basis for the flow state is increasingly understood to be a phenomenon called transient hypofrontality.38 This refers to the temporary down-regulation, or quieting, of activity in the prefrontal cortex (PFC). The PFC is the brain's executive control center, responsible for higher-order cognitive functions like long-term planning, abstract thought, and self-referential processing (the inner monologue or critic).38 By temporarily taking this metabolically expensive and relatively slow part of the brain "offline," neural resources are reallocated to the sensorimotor networks directly involved in the physical task. This explains several key characteristics of flow: the loss of self-consciousness (the inner critic is silenced), the distortion of time (the part of the brain that tracks it is less active), and the feeling of automaticity, as highly trained motor skills are executed without interference from conscious thought.44

4.4. Flow and the Default Mode Network (DMN)

This concept of hypofrontality is closely linked to the Default Mode Network (DMN). The DMN is a large-scale brain network, with key nodes in the medial prefrontal cortex and posterior cingulate cortex, that is most active when the mind is at rest and engaged in self-referential thought—daydreaming, worrying about the future, or ruminating on the past.45 Both the flow state and practices like meditation are characterized by a significant deactivation of the DMN.45 This neural silencing is the objective brain state that corresponds to the subjective experience of losing one's "ego" and becoming completely absorbed in the present moment. The mental chatter that normally consumes a large portion of the brain's energy fades away, allowing for a state of pure, focused action.41 The "effortless" feeling of flow is, therefore, a direct result of profound neural efficiency. By shutting down the energy-intensive PFC and DMN, the brain dedicates its full capacity to the well-practiced motor programs required for the task, leading to a state of peak performance that feels fluid and instinctual.

Section 5: Synergy in Motion: A Unified Model of the Peak Experience

The extraordinary experience of sustained, effortless sprinting is not the result of any single factor but rather the product of a powerful synergy between physiology, neurochemistry, and psychology. These three elements converge and create a self-reinforcing positive feedback loop that enables a level of performance far beyond normal capabilities.

5.1. The Convergence of Body, Brain, and Mind

The peak experience unfolds through a specific causal sequence where each stage enables the next, creating an upward spiral of performance. Physiological Trigger: The initial period of intense, high-effort running pushes the body beyond its comfort zone and past its lactate threshold. This stress acts as the necessary trigger for the adaptive metabolic shift of the second wind. The body learns to efficiently clear and utilize lactate, stabilizing its energy supply and reducing the physiological signals of distress. Neurochemical Enablement: The sustained, high-intensity exercise, now made physiologically tolerable by the second wind, provides the stimulus required for a significant release of endocannabinoids. This neurochemical cascade produces the runner's high, which powerfully masks residual pain, reduces anxiety about the effort, and activates dopamine-driven reward pathways, creating a strong motivation to continue. Psychological Immersion: The combination of a simplified goal (maintain the sprint), a dramatic reduction in physical discomfort (due to the second wind and runner's high), and heightened, dopamine-fueled focus creates the ideal conditions for transient hypofrontality. The prefrontal cortex quiets down, the Default Mode Network deactivates, and the individual enters a profound flow state, where the action feels automatic and effortless. This sequence demonstrates a clear feedback loop: the physiological adaptation enables the neurochemical reward, which in turn facilitates the psychological state of immersion. This psychological state, by reducing the perception of effort, allows the physical exertion to be sustained, perpetuating the cycle.

5.2. The Antithesis: "Hitting the Wall" (Bonking)

To fully appreciate the metabolic success of the peak experience, it is useful to contrast it with its antithesis: "hitting the wall," or "bonking".50 This phenomenon is not a metabolic adaptation but a metabolic crisis. It is caused by the catastrophic depletion of the body's primary fuel for high-intensity exercise: glycogen stored in the muscles and liver.50 When an athlete "bonks," they experience a sudden and severe onset of fatigue, dizziness, muscle weakness, and a dramatic loss of energy.50 Their body has run out of readily available carbohydrates and is forced to rely on the much slower and less efficient process of converting fat into usable energy, which cannot sustain high-intensity effort. The experience described by the user was one of optimal fuel utilization (the second wind), whereas hitting the wall is a state of acute fuel depletion. This stark contrast highlights that the peak state is a triumph of metabolic efficiency, not a prelude to collapse.

Characteristic Peak Experience (Second Wind/Runner's High/Flow) Hitting the Wall (Bonking) Overtraining Syndrome Primary Cause Metabolic efficiency & neurochemical reward. Glycogen depletion. Chronic under-recovery & systemic inflammation.54 Subjective Feeling Euphoria, effortless, powerful, focused.22 Sudden, catastrophic fatigue, weakness, dizziness.50 Persistent fatigue, irritability, lack of motivation.55 Performance Sudden increase or sustained peak. Sudden, dramatic drop. Chronic decline or plateau.55 Key Physiology Efficient lactate utilization, stable HR/VO2​.3 Depleted glycogen stores, hypoglycemia.50 HPA axis dysregulation, elevated resting HR.54 Key Neurochemistry High endocannabinoids, dopamine.23 Central fatigue (serotonin imbalance).37 Neurohormonal perturbations, inflammation.54

Section 6: The Individual Factor: Why Experiences Vary

The capacity to achieve this tripartite state of peak performance is not universal. It represents a rare convergence of an individual's genetic makeup, their level of physical conditioning, and their psychological state at a specific moment in time.

6.1. The Genetic Blueprint: Predisposition to the Peak Experience

Individual genetic variations can significantly influence the neurochemical response to exercise, predisposing some individuals to more readily experience these states. FAAH Polymorphism (rs324420): The Fatty Acid Amide Hydrolase (FAAH) gene codes for the primary enzyme that degrades the endocannabinoid anandamide. A common polymorphism (rs324420) results in a C-to-A substitution. Individuals carrying the 'A' allele produce a less stable FAAH enzyme, which leads to reduced anandamide breakdown and consequently higher circulating levels of this "bliss molecule." These individuals may be genetically predisposed to experience a more robust and easily triggered runner's high.58 Dopamine Receptor Genes (e.g., DRD2): Polymorphisms in genes such as DRD2, which codes for a key dopamine receptor, are associated with differences in reward sensitivity, motivation, and personality traits like persistence and risk-taking.62 Certain genotypes may confer a greater sense of pleasure and motivation from the dopamine release associated with intense exercise. Serotonin Transporter Gene (5-HTTLPR): Variations in the serotonin transporter gene are linked to mood regulation and an individual's emotional response to stress. This could influence how an athlete perceives and copes with the physical and mental stress of high-intensity training, potentially impacting their ability to enter a positive affective state like flow.66

6.2. The Role of Training and Conditioning

A high level of physical fitness is a non-negotiable prerequisite for this experience. An untrained or moderately trained individual would likely succumb to physiological fatigue long before reaching the duration and intensity required to trigger the full neurochemical cascade. A well-conditioned endurance athlete possesses several key advantages: A higher lactate threshold, allowing them to sustain a faster pace before significant metabolic acidosis occurs.2 Greater mitochondrial density and oxidative enzyme capacity, improving the efficiency of aerobic metabolism.69 A more robust and efficient cardiovascular system for oxygen delivery. These adaptations make it physiologically possible to reach the "sweet spot" of intensity (around 70-80% max effort) and duration (30+ minutes) needed to activate the ECS and create the conditions for flow.19

6.3. Mental and Environmental Factors

The final piece of the puzzle is the individual's psychological and environmental state at the time of exercise. Mindset: Entering a workout with a calm, focused mindset, free from excessive stress or anxiety, facilitates entry into a flow state. High pre-existing stress levels can act as a barrier, preventing the necessary mental immersion.19 Environment: Minimizing external distractions is crucial for the intense concentration required for flow. Running on a treadmill, as in the reported experience, can inadvertently serve as a form of sensory control, allowing the individual to focus entirely on the internal rhythm of the activity. Studies also suggest that running outdoors in a natural environment may enhance anandamide production more effectively than indoor running, though both can be conducive to the experience.22

Section 7: Conclusion and Recommendations: Harnessing the Body's Innate Potential

7.1. Summary of the Unified Model

The reported experience of sprinting for 20 minutes with a surge of power and no fatigue can be understood as a rare but scientifically valid peak performance state. It arises from the synergistic convergence of three phenomena: a second wind provides the physiological platform for sustained high-intensity effort; a runner's high, driven by the endocannabinoid system, provides the neurochemical reward that masks pain and motivates continued effort; and a flow state provides the psychological framework of effortless focus and immersion. This is not a supernatural event but a manifestation of the human body's remarkable, evolutionarily-honed potential.

7.2. Evidence-Based Strategies to Increase Likelihood of Peak Experiences

While this state cannot be forced on demand due to its complex and multifactorial nature, certain training and mental preparation strategies can increase the probability of its occurrence. Training Protocols: Build an Aerobic Base: Consistent endurance training is fundamental to increasing the lactate threshold and improving metabolic efficiency. This forms the physiological foundation. Incorporate Intensity: The optimal stimulus for endocannabinoid release appears to be sustained, moderate-to-high intensity exercise (70-80% of max heart rate) for at least 30-45 minutes.19 Use HIIT Strategically: High-Intensity Interval Training (HIIT) is an effective method for improving maximal oxygen uptake (VO2​ max) and anaerobic capacity, which can make sustained high-intensity efforts feel more manageable.69 Mental Preparation: Practice Mindfulness and Visualization: Techniques such as mindfulness meditation train the brain to maintain present-moment focus and quiet the Default Mode Network. This practice directly strengthens the "mental muscle" required to enter a flow state during activity.74 Visualizing a successful and effortless performance can also prime the brain for that experience. Set Clear Goals: Before a workout, establish a simple, clear objective. This helps to focus attention and provides the unambiguous goal structure necessary for flow. Environmental Control: Minimize Distractions: Choose a time and place for key workouts where interruptions are unlikely. On a treadmill, this might involve focusing on a fixed point or using rhythmic, non-lyrical music to facilitate immersion and block out distractions.22 Listen to Your Body: It is critical to differentiate between the productive discomfort that often precedes a second wind and the persistent warning signs of overtraining syndrome. Chronic fatigue, elevated resting heart rate, mood disturbances, and a lack of motivation are signs that the body needs rest, not a harder push. Ignoring these signals can lead to injury and burnout, the antithesis of the peak state.54

7.3. Final Perspective

The experience described is a powerful glimpse into the latent potential encoded within human physiology and neurobiology. It is a modern manifestation of an ancient survival mechanism, a reward system forged by the evolutionary pressures of persistence hunting. Understanding the science behind this state does not diminish its magic; rather, it deepens our appreciation for the intricate and elegant systems that allow the human body and mind, under the right conditions, to achieve performance that feels truly extraordinary. 참고 자료 Anaerobic Exercise - Physiopedia, 7월 31, 2025에 액세스, https://www.physio-pedia.com/Anaerobic_Exercise Lactate Threshold - Physiopedia, 7월 31, 2025에 액세스, https://www.physio-pedia.com/Lactate_Threshold The "second wind" in McArdle's disease patients during a second bout of constant work rate submaximal exercise, 7월 31, 2025에 액세스, https://journals.physiology.org/doi/prev/20140320-aop/pdf/10.1152/japplphysiol.01063.2013 The “second wind” in McArdle's disease patients during a second bout of constant work rate submaximal exercise - American Journal of Physiology, 7월 31, 2025에 액세스, https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.01063.2013 Loss of Skeletal Muscle HIF-1α Results in Altered Exercise Endurance - PMC, 7월 31, 2025에 액세스, https://pmc.ncbi.nlm.nih.gov/articles/PMC514537/ (PDF) The "second wind" in McArdle's disease patients during a second bout of constant work rate submaximal exercise - ResearchGate, 7월 31, 2025에 액세스, https://www.researchgate.net/publication/260998269_The_second_wind_in_McArdle's_disease_patients_during_a_second_bout_of_constant_work_rate_submaximal_exercise The Second Wind in McArdle Patients: Fitness Matters - PMC, 7월 31, 2025에 액세스, https://pmc.ncbi.nlm.nih.gov/articles/PMC8555491/ Study of the relationship between the aerobic capacity (VO2 max) and the rating of perceived exertion based on the measurement of heart beat in the metal industries Esfahan, 7월 31, 2025에 액세스, https://pmc.ncbi.nlm.nih.gov/articles/PMC4114002/ Oxygen uptake, heart rate, and ratings of perceived exertion at the PWCVo2 - PubMed, 7월 31, 2025에 액세스, https://pubmed.ncbi.nlm.nih.gov/19528845/ Comparison of Physiological and Perceptional Responses to 5-m Forward, Forward-Backward, and Lateral Shuttle Running - Frontiers, 7월 31, 2025에 액세스, https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.780699/pdf The Truth Behind 'Runner's High' and Other Mental Benefits of Running, 7월 31, 2025에 액세스, https://www.hopkinsmedicine.org/health/wellness-and-prevention/the-truth-behind-runners-high-and-other-mental-benefits-of-running The Truth Behind the 'Runner's High' - BrainWise Media, 7월 31, 2025에 액세스, https://brainwisemedia.com/the-truth-behind-the-runners-high/ Exercise and Depression: How Physical Activity Can Help - WebMD, 7월 31, 2025에 액세스, https://www.webmd.com/depression/exercise-depression Endorphins in the brain's reinforcement system | EBSCO Research Starters, 7월 31, 2025에 액세스, https://www.ebsco.com/research-starters/psychology/endorphins-brains-reinforcement-system Roles of β-Endorphin in Stress, Behavior, Neuroinflammation, and Brain Energy Metabolism, 7월 31, 2025에 액세스, https://www.mdpi.com/1422-0067/22/1/338 Endorphins: What They Are and How to Boost Them - Cleveland Clinic, 7월 31, 2025에 액세스, https://my.clevelandclinic.org/health/body/23040-endorphins The Role of Endorphins in Exercise: A Review of Current Knowledge - jospt, 7월 31, 2025에 액세스, https://www.jospt.org/doi/pdf/10.2519/jospt.1983.4.3.169 Do Endocannabinoids Cause the Runner's High? Evidence and Open Questions - PMC, 7월 31, 2025에 액세스, https://pmc.ncbi.nlm.nih.gov/articles/PMC10159215/ The Science Behind the Runner's High: What Really Happens in Your Brain - Craftsbury Outdoor Center, 7월 31, 2025에 액세스, https://www.craftsbury.com/blog/the-science-behind-the-runners-high-what-really-happens-in-your-brain Exercise for the brain: all about endorphins - Institute for Optimum Nutrition, 7월 31, 2025에 액세스, https://ion.ac.uk/articles/exercise-brain-health Endocannabinoid system - Wikipedia, 7월 31, 2025에 액세스, https://en.wikipedia.org/wiki/Endocannabinoid_system The Real Runner's High: The Science Behind the Ultimate Flow State - Puresport, 7월 31, 2025에 액세스, https://puresport.co/blogs/the-run-down/the-real-runner-s-high-the-science-behind-the-ultimate-flow-state (PDF) Wired to run: Exercise-induced endocannabinoid signaling in humans and cursorial mammals with implications for the 'runner's high' - ResearchGate, 7월 31, 2025에 액세스, https://www.researchgate.net/publication/221971138_Wired_to_run_Exercise-induced_endocannabinoid_signaling_in_humans_and_cursorial_mammals_with_implications_for_the_'runner's_high' The 'runner's high' may result from molecules called cannabinoids – the body's own version of THC and CBD - Today@Wayne, 7월 31, 2025에 액세스, https://today.wayne.edu/news/2022/01/03/the-runners-high-may-result-from-molecules-called-cannabinoids-the-bodys-own-version-of-thc-and-cbd-46709 The Endocannabinoid System and Physical Exercise - PMC - PubMed Central, 7월 31, 2025에 액세스, https://pmc.ncbi.nlm.nih.gov/articles/PMC9916354/ (PDF) Endocannabinoids and exercise - ResearchGate, 7월 31, 2025에 액세스, https://www.researchgate.net/publication/8325784_Endocannabinoids_and_exercise A runner's high depends on cannabinoid receptors in mice - PMC - PubMed Central, 7월 31, 2025에 액세스, https://pmc.ncbi.nlm.nih.gov/articles/PMC4620874/ Endocannabinoids and exercise, 7월 31, 2025에 액세스, https://e-l.unifi.it/pluginfile.php/878388/mod_folder/content/0/reviewendocannabinoidsexercise.pdf?forcedownload=1 Cannabinoid Modulation of Dopamine Release During Motivation, Periodic Reinforcement, Exploratory Behavior, Habit Formation, and Attention - Frontiers, 7월 31, 2025에 액세스, https://www.frontiersin.org/journals/synaptic-neuroscience/articles/10.3389/fnsyn.2021.660218/full Five Surprising Ways Exercise Changes Your Brain - Greater Good Science Center, 7월 31, 2025에 액세스, https://greatergood.berkeley.edu/article/item/five_surprising_ways_exercise_changes_your_brain Regular Exercise Benefits Both Mind and Body: A Psychiatrist Explains - My Doctor Online, 7월 31, 2025에 액세스, https://mydoctor.kaiserpermanente.org/mas/news/regular-exercise-benefits-both-mind-and-body-a-psychiatrist-explains-1903986 Endurance Running & Persistence Hunting, 7월 31, 2025에 액세스, https://carrier.biology.utah.edu/Persistence%20Hunting.html Fragments of the hunt Persistence hunting approach to rock art Mikko R Ijäs Hunter gatherer research Published but without - Tuhat - University of Helsinki, 7월 31, 2025에 액세스, https://tuhat.helsinki.fi/ws/files/273942616/Fragments_of_the_hunt_Persistence_hunting_approach_to_rock_art_Mikko_R_Ija_s_Hunter_gatherer_research_Published_but_without_layout.pdf Runner's High: How Evolution Explains It - Promises Behavioral Health, 7월 31, 2025에 액세스, https://www.promises.com/addiction-blog/runners-high-how-evolution-explains-it/ Why we get a "runner's high" - Chatelaine, 7월 31, 2025에 액세스, https://chatelaine.com/health/fitness/why-we-get-a-runners-high/ Why does running give you a high? A look at the science | - ideas.ted.com, 7월 31, 2025에 액세스, https://ideas.ted.com/why-does-running-give-you-a-high-heres-the-science/ Why Athletes Bonk - Indialantic Youth Soccer Association, 7월 31, 2025에 액세스, https://www.iysasoccer.com/why-athletes-bonk/ Flow (psychology) | EBSCO Research Starters, 7월 31, 2025에 액세스, https://www.ebsco.com/research-starters/psychology/flow-psychology Flow (psychology) - Wikipedia, 7월 31, 2025에 액세스, https://en.wikipedia.org/wiki/Flow_(psychology) Mihaly Csikszentmihalyi - The Flow State, Definition & How-to - Still Mind Florida, 7월 31, 2025에 액세스, https://stillmindflorida.com/mental-health/mihaly-csikszentmihalyi-the-flow-state-definition-how-to/ What Is Flow in Positive Psychology? (Incl. 10+ Activities), 7월 31, 2025에 액세스, https://positivepsychology.com/what-is-flow/ Mihály Csíkszentmihályi: The Father of Flow - Positive Psychology, 7월 31, 2025에 액세스, https://positivepsychology.com/mihaly-csikszentmihalyi-father-of-flow/ Achieving Flow: An Exploratory Investigation of Elite College Athletes and Musicians - PMC, 7월 31, 2025에 액세스, https://pmc.ncbi.nlm.nih.gov/articles/PMC9009586/ The Flow State: The Science of Running in "The Zone", 7월 31, 2025에 액세스, https://www.mcmillanrunning.com/the-flow-state-the-science-of-running-in-the-zone/ Meditation experience is associated with differences in default mode network activity and connectivity, 7월 31, 2025에 액세스, https://pmc.ncbi.nlm.nih.gov/articles/PMC3250176/ Default Mode Network - The root of suffering. : r/Meditation - Reddit, 7월 31, 2025에 액세스, https://www.reddit.com/r/Meditation/comments/oipzam/default_mode_network_the_root_of_suffering/ Neural signatures of experimentally induced flow experiences identified in a typical fMRI block design with BOLD imaging - PubMed Central, 7월 31, 2025에 액세스, https://pmc.ncbi.nlm.nih.gov/articles/PMC4769635/ Positive Neuroscience: Comparing the Neural Correlates of Meditation and Creative Flow, 7월 31, 2025에 액세스, https://www.jsr.org/hs/index.php/path/article/view/5264 Differences in Default Mode Network activation? : r/neuro - Reddit, 7월 31, 2025에 액세스, https://www.reddit.com/r/neuro/comments/7v12pg/differences_in_default_mode_network_activation/ Hitting the wall - Wikipedia, 7월 31, 2025에 액세스, https://en.wikipedia.org/wiki/Hitting_the_wall What is 'hitting the wall' during a marathon and how can you avoid it? - Runner's World, 7월 31, 2025에 액세스, https://www.runnersworld.com/uk/training/marathon/a774858/how-to-avoid-the-wall-and-cope-if-you-hit-it/ What happens when you 'hit the wall'? - Live Science, 7월 31, 2025에 액세스, https://www.livescience.com/health/exercise/what-happens-when-you-hit-the-wall Metabolic Factors Limiting Performance in Marathon Runners - PMC - PubMed Central, 7월 31, 2025에 액세스, https://pmc.ncbi.nlm.nih.gov/articles/PMC2958805/ Overtraining Syndrome: A Practical Guide - PMC - PubMed Central, 7월 31, 2025에 액세스, https://pmc.ncbi.nlm.nih.gov/articles/PMC3435910/ Overtraining: What It Is, Symptoms, and Recovery - HSS, 7월 31, 2025에 액세스, https://www.hss.edu/health-library/move-better/overtraining 6 Signs of Overtraining in Runners: How to Know When You Need a Break | Fleet Feet, 7월 31, 2025에 액세스, https://www.fleetfeet.com/blog/6-signs-of-overtraining-in-runners-how-to-know-when-you-need-a-break Overtraining Syndrome: Symptoms, Causes & Treatment Options - Cleveland Clinic, 7월 31, 2025에 액세스, https://my.clevelandclinic.org/health/diseases/overtraining-syndrome FAAH rs324420 Polymorphism: Biological Pathways, Impact on Elite Athletic Performance and Insights for Sport Medicine - MDPI, 7월 31, 2025에 액세스, https://www.mdpi.com/2073-4425/14/10/1946 A genetic variant of fatty acid amide hydrolase (FAAH) exacerbates hormone-mediated orexigenic feeding in mice | eLife, 7월 31, 2025에 액세스, https://elifesciences.org/articles/81919 Circulating Endocannabinoids and the Polymorphism 385C>A in Fatty Acid Amide Hydrolase (FAAH) Gene May Identify the Obesity Phenotype Related to Cardiometabolic Risk: A Study Conducted in a Brazilian Population of Complex Interethnic Admixture | PLOS One, 7월 31, 2025에 액세스, https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0142728 Functional Variation in the FAAH Gene Is Directly Associated with Subjective Well-Being and Indirectly Associated with Problematic Alcohol Use - MDPI, 7월 31, 2025에 액세스, https://www.mdpi.com/2073-4425/14/9/1826 Association between Polymorphism rs1799732 of DRD2 Dopamine Receptor Gene and Personality Traits among MMA Athletes - Bohrium, 7월 31, 2025에 액세스, https://www.bohrium.com/paper-details/association-between-polymorphism-rs1799732-of-drd2-dopamine-receptor-gene-and-personality-traits-among-mma-athletes/811949329169252353-8159 Association analysis of the dopaminergic receptor 2 gene Tag1B rs1079597 and personality traits among a cohort of professional athletes - Termedia, 7월 31, 2025에 액세스, https://www.termedia.pl/Journal/-78/pdf-54097-10 Association between Polymorphism rs1799732 of DRD2 Dopamine Receptor Gene and Personality Traits among MMA Athletes - ResearchGate, 7월 31, 2025에 액세스, https://www.researchgate.net/publication/353739996_Association_between_Polymorphism_rs1799732_of_DRD2_Dopamine_Receptor_Gene_and_Personality_Traits_among_MMA_Athletes Relationship between Taq1A Dopamine D2 Receptor Polymorphism and Motivation to Exercise and levels of Voluntary Physical Activit - Dialnet, 7월 31, 2025에 액세스, https://dialnet.unirioja.es/descarga/articulo/7718334.pdf Negative cognitive response to a sad mood induction: Associations with polymorphisms of the serotonin transporter (5-HTTLPR) gene - ResearchGate, 7월 31, 2025에 액세스, https://www.researchgate.net/publication/263343238_Negative_cognitive_response_to_a_sad_mood_induction_Associations_with_polymorphisms_of_the_serotonin_transporter_5-HTTLPR_gene Efficacy of exercise in reducing depressive symptoms across 5-HTTLPR genotypes - PubMed, 7월 31, 2025에 액세스, https://pubmed.ncbi.nlm.nih.gov/20351589/ Association between 5-HTTLPR genotype and Profile of Mood States... - ResearchGate, 7월 31, 2025에 액세스, https://www.researchgate.net/figure/Association-between-5-HTTLPR-genotype-and-Profile-of-Mood-States-POMS-Mean-SD-P_fig5_303795041 HIIT vs. Continuous Cardiovascular Exercise, 7월 31, 2025에 액세스, https://www.unm.edu/~lkravitz/Article%20folder/HIITvsCardio.html Journal of Applied Sport Psychology Factors influencing the occurrence of flow state in elite athletes - Sci-Hub, 7월 31, 2025에 액세스, https://dacemirror.sci-hub.se/journal-article/8310be07319923fad31a0751c617fe49/jackson1995.pdf HIIT Vs Steady-State Cardio – How To Choose? | Polar Blog, 7월 31, 2025에 액세스, https://www.polar.com/blog/hiit-or-steady-state-cardio/ HIIT vs. Steady State Cardio: Which One Is Best for Your Clients? - ACE Fitness, 7월 31, 2025에 액세스, https://www.acefitness.org/resources/pros/expert-articles/5563/steady-state-vs-interval-training-which-one-is-best-for-your-clients/ HIIT vs. Steady State Cardio—Which Reigns Supreme for Optimal Fitness? - Verywell Fit, 7월 31, 2025에 액세스, https://www.verywellfit.com/is-hiit-training-or-steady-state-cardio-better-4126506 Sports psychology: Mental preparation for competition - St. Charles Health System, 7월 31, 2025에 액세스, https://stcharleshealthcare.org/news/sports-psychology-mental-preparation-competition 14 Sports Psychology Techniques & Tips for Coaching Athletes, 7월 31, 2025에 액세스, https://positivepsychology.com/sports-psychology-techniques/ www.successstartswithin.com, 7월 31, 2025에 액세스, https://www.successstartswithin.com/sports-psychology-articles/mindfulness-training-for-athletes/sports-flow-how-to-achieve-flow-in-sports/#:~:text=The%20reason%20you%20want%20to,your%20chances%20of%20experiencing%20flow. Sports Flow: How to Achieve Flow in Sports | Success Starts Within, 7월 31, 2025에 액세스, https://www.successstartswithin.com/sports-psychology-articles/mindfulness-training-for-athletes/sports-flow-how-to-achieve-flow-in-sports/ How to Reach Flow States | Sport Psychology - YouTube, 7월 31, 2025에 액세스, https://www.youtube.com/watch?v=bsSUbnFCtLI How to Enter Flow State: 6 Activities & Trainings - Positive Psychology, 7월 31, 2025에 액세스, https://positivepsychology.com/flow-activities/